2015

Ofer P, Heidegger I, Eder IE, Schöpf B, Neuwirt H, Geley S, Klocker H, Massoner P (2015). Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo. Mol Endocrinol. 2015 Dec;29(12):1694-707. doi: 10.1210/me.2015-1073. PMID: 26452103.

Fava LL, Rainer J, Haschka MD, Geley S, Villunger A (2015). Beclin 1 is dispensable for chromosome congression and proper outer kinetochore assembly. EMBO Rep. 2015 Oct;16(10):1233-6. doi: 10.15252/embr.201540731. PMID: 26297610.

Pasqualini L, Bu H, Puhr M, Narisu N, Rainer J, Schlick B, Schäfer G, Angelova M, Trajanoski Z, Börno ST, Schweiger MR, Fuchsberger C, Klocker H (2015). miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. Mol Endocrinol. 2015 Jul;29(7):1037-54. doi: 10.1210/me.2014-1358. PMID: 26052614.

Nicholson L, Evans CA, Matheson E, Minto L, Keilty C, Sanichar M, Case M, Schwab C, Williamson D, Rainer J, Harrison CJ, Kofler R, Hall AG, Redfern CP, Whetton AD, Irving JA (2015). Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition. Br J Haematol. 2015 Nov;171(4):595-605. doi: 10.1111/bjh.13647. PMID: 26310606.

Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A (2015). The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Sci Rep 5:11268. doi: 10.1038/srep11268. PMID: 26062895.

Haschka MD, Soratroi C, Kirschnek S, Häcker G, Hilbe R, Geley S, Villunger A, Fava LL (2015). The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest. Nat Commun. 2015 Apr 29;6:6891. doi: 10.1038/ncomms7891. PMID: 25922916.

Watschinger K, Keller MA, McNeill E, Alam MT, Lai S, Sailer S, Rauch V, Patel J, Hermetter A, Golderer G, Geley S, Werner-Felmayer G, Plumb RS, Astarita G, Ralser M, Channon KM, Werner ER (2015). Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2431-6. doi: 10.1073/pnas.1414887112. PMID: 25675482.

Piatti P, Lim CY, Nat R, Villunger A, Geley S, Shue YT, Soratroi C, Moser M, Lusser A. (2015) Embryonic stem cell differentiation requires full length Chd1. Sci Rep. 2015 Jan 26;5:8007. doi: 10.1038/srep08007. PMID: 25620209.

Schinnerl D, Fortschegger K, Kauer M, Marchante JR, Kofler R, Den Boer ML, Strehl S (2015). The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia Blood. 2015 Feb 19;125(8):1282-91. doi: 10.1182/blood-2014-04-570960. PMID: 25515960.

Vosper J, Masuccio A, Kullmann M, Ploner C, Geley S, Hengst L (2015). Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation. Oncotarget. 2015 Feb 20;6(5):2889-902. PMID: 25605247.

2014

Puhr M, Hoefer J, Neuwirt H, Eder IE, Kern J, Schäfer G, Geley S, Heidegger I, Klocker H, Culig Z (2014). PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells. Oncotarget. 2014 Dec 15;5(23):12043-56. PMID: 25474038.

Barisic M, Aguiar P, Geley S, Maiato H. (2014). Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces. Nat Cell Biol. 2014 Dec;16(12):1249-56. doi: 10.1038/ncb3060. PMID: 25383660.

Salcher S, Hagenbuchner J, Geiger K, Seiter MA, Rainer J, Kofler R, Hermann M, Kiechl-Kohlendorfer U, Ausserlechner MJ, Obexer P. C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma. Mol Cancer13: 224. PMID: 25261981.

Spilka, R., Ernst, C., Bergler, H., Rainer, J., Flechsig, S., Vogetseder, A. et al. (2014). eIF3a is over-expressed in urinary bladder cancer and influences its phenotype independent of translation initiation. Cell Oncol (Dordr). 2014 Aug;37(4):253-67. doi: 10.1007/s13402-014-0181-9. PMID: 25070653.

Bindreither D, Ecker S, Gschirr B, Kofler A, Kofler R, Rainer J (2014). The synthetic glucocorticoids prednisolone and dexamethasone regulate the same genes in acute lymphoblastic leukemia cells. BMC Genomics. 2014 Aug 7;15:662. doi: 10.1186/1471-2164-15-662. BMC Genomics. 2014 Aug 7;15:662. doi: 10.1186/1471-2164-15-662. PMID: 25103118.

Sigl, R., Ploner, C., Shivalingaiah, G., Kofler, R. & Geley, S. (2014). Development of a multipurpose GATEWAY-based lentiviral tetracycline-regulated conditional RNAi system (GLTR). PLoS One. 2014 May 19;9(5):e97764. doi: 10.1371/journal.pone.0097764. eCollection 2014. PMID: 24841113.

Niedan S, Kauer M, Aryee DN, Kofler R, Schwentner R, Meier A, Pötschger U, Kontny U, Kovar H (2014). Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma. Oncogene. 2014 Jul 24;33(30):3927-38. doi: 10.1038/onc.2013.361. PMID: 23995784.

Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, Lusser A, Flockerzi V, Flucher BE. (2014). Differential Neuronal Targeting of a New and Two Known Calcium Channel beta4 Subunit Splice Variants Correlates with Their Regulation of Gene Expression J Neurosci. 2014 Jan 22;34(4):1446-61. doi: 10.1523/JNEUROSCI.3935-13.2014. PMID: 24453333.

Hoefer J, Kern J, Ofer P, Eder IE, Schäfer G, Dietrich D, Kristiansen G, Geley S, Rainer J, Gunsilius E, Klocker H, Culig Z, Puhr M. (2014). SOCS2 correlates with malignancy and exerts growth promoting effects in prostate cancer. Endocr Relat Cancer. 2014 Jan 30;21(2):175-87. doi: 10.1530/ERC-13-0446. PMID: 24280133.

Thoeni CE, Vogel GF, Tancevski I, Geley S, Lechner S, Pfaller K, Hess MW, Müller T, Janecke AR, Avitzur Y, Muise A, Cutz E, Huber LA (2014). Microvillus inclusion disease: loss of Myosin Vb disrupts intracellular traffic and cell polarity. Traffic. 2014 Jan;15(1):22-42. doi: 10.1111/tra.12131. PMID: 24138727.

2013

Aneichyk T, Bindreither D, Mantinger C, Grazio D, Goetsch K, Kofler R, Rainer J (2013). Translational profiling in childhood acute lymphoblastic leukemia: no evidence for glucocorticoid regulation of mRNA translation. BMC Genomics. 2013 Dec 1;14:844. doi: 10.1186/1471-2164-14-844. PMID: 24289529.

Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A (2013). Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.. Cell Death Dis. 2013 Dec 5;4:e942. doi: 10.1038/cddis.2013.470. PMID: 24309929.

Aryee DN, Niedan S, Ban J, Schwentner R, Muehlbacher K, Kauer M, Kofler R, Kovar H (2013). Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma. Br J Cancer. 2013 Nov 12;109(10):2696-704. doi: 10.1038/bjc.2013.635. PMID: 24129240.

Kullmann MK, Grubbauer C, Goetsch K, Jäkel H, Podmirseg SR, Trockenbacher A, Ploner C, Cato AC, Weiss C, Kofler R, Hengst L. The p27-Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells. Cell Cycle. 2013 Aug 15;12(16):2625-35. doi: 10.4161/cc.25622. PMID: 23907123.

Martowicz A, Rainer J, Lelong J, Spizzo G, Gastl G, Untergasser G. EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth. Mol Cancer. 2013 Jun 10;12:56. doi: 10.1186/1476-4598-12-56. PMID: 23758908.

Gründlinger M, Yasmin S, Lechner BE, Geley S, Schrettl M, Hynes M, Haas H (2013). Fungal siderophore biosynthesis is partially localized in peroxisomes. Mol Microbiol. 2013 Jun;88(5):862-75. doi: 10.1111/mmi.12225. PMID: 23617799.

Hohsfield LA, Geley S, Reindl M, Humpel C (2013). The generation of NGF-secreting primary rat monocytes: a comparison of different transfer methods. J Immunol Methods. 2013 May 31;391(1-2):112-24. doi: 10.1016/j.jim.2013.02.016. PMID: 23474426.

Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28;495(7442):474-80. doi: 10.1038/nature11923. PMID: 23474986.

Labi V, Bertele D, Woess C, Tischner D, Bock FJ, Schwemmers S, Pahl HL, Geley S, Kunze M, Niemeyer CM, Villunger A, Erlacher M (2013). Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf. EMBO Mol Med. 2013 Jan;5(1):122-36. doi: 10.1002/emmm.201201235. PMID: 23180554.

Mansha M, Hussain A, Kofler A, Grubbauer C, Goetsch K, Ploner C, Kofler R (2013). "Bam," a novel glucocorticoid-induced BH3-only transcript from the BCL2L11/Bim locus, does not appear to be translated. Leuk Lymphoma. 2013 Feb;54(2):353-8. doi: 10.3109/10428194.2012.708928. PMID: 22762551.

2012

Fava LL, Bock FJ, Geley S, Villunger A (2012). Caspase-2 at a glance. J Cell Sci. 2012 Dec 15;125(Pt 24):5911-5. doi: 10.1242/jcs.115105. PMID: 23447670.

Gsaller F, Eisendle M, Lechner BE, Schrettl M, Lindner H, Müller D, Geley S, Haas H (2012). The interplay between vacuolar and siderophore-mediated iron storage in Aspergillus fumigatus. Metallomics. 2012 Dec;4(12):1262-70. doi: 10.1039/c2mt20179h. PMID: 23151814.

Wandke C, Barisic M, Sigl R, Rauch V, Wolf F, Amaro AC, Tan CH, Pereira AJ, Kutay U, Maiato H, Meraldi P, Geley S (2012). Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis. J Cell Biol. 2012 Sep 3;198(5):847-63. doi: 10.1083/jcb.201110060. PMID: 22945934.

Mahlknecht P, Stemberger S, Sprenger F, Rainer J, Hametner E, Kirchmair R, Grabmer C, Scherfler C, Wenning GK, Seppi K, Poewe W, Reindl M (2012). An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes. Proteome Sci. 2012 Nov 23;10(1):71. doi: 10.1186/1477-5956-10-71. PMID: 23173604.

Mikolcevic P, Rainer J, Geley S (2012). Orphan kinases turn eccentric: a new class of cyclin Y-activated, membrane-targeted CDKs. Cell Cycle. 2012 Oct 15;11(20):3758-68. doi: 10.4161/cc.21592. PMID: 22895054.

Wasim M, Mansha M, Kofler A, Awan AR, Babar ME, Kofler R. Promyelocytic leukemia zinc finger protein (PLZF) enhances glucocorticoid-induced apoptosis in leukemic cell line NALM6. Pak J Pharm Sci. 2012 Jul;25(3):617-21. PMID: 22713950.

Ottina E, Grespi F, Tischner D, Soratroi C, Geley S, Ploner A, Reichardt HM, Villunger A, Herold MJ (2012). Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice. Blood. 2012 Jun 21;119(25):6032-42. doi: 10.1182/blood-2011-12-399089. PMID: 22581448.

Goebel G, Berger R, Strasak AM, Egle D, Müller-Holzner E, Schmidt S, Rainer J, Presul E, Parson W, Lang S, Jones A, Widschwendter M, Fiegl H (2012). Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients. Br J Cancer. 2012 Jan 3;106(1):189-98. doi: 10.1038/bjc.2011.510. PMID: 22108517.

Mikolcevic P, Sigl R, Rauch V, Hess MW, Pfaller K, Barisic M, Pelliniemi LJ, Boesl M, Geley S (2012). Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mol Cell Biol. 2012 Feb;32(4):868-79. doi: 10.1128/MCB.06261-11. PMID: 22184064.

Rainer J, Lelong J, Bindreither D, Mantinger C, Ploner C, Geley S, Kofler R (2012). Research resource: transcriptional response to glucocorticoids in childhood acute lymphoblastic leukemia. Mol Mol Endocrinol. 2012 Jan;26(1):178-93. doi: 10.1210/me.2011-1213. PMID: 22074950.

2011

Eberhart K, Rainer J, Bindreither D, Ritter I, Gnaiger E, Kofler R, Oefner PJ, Renner K (2011). Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia. Biochim Biophys Acta. 2011 Jun;1807(6):719-25. doi: 10.1016/j.bbabio.2010.12.010. PMID: 21237131.

Oppl B, Kofler A, Schwarz S, Rainer J, Kofler R. Establishing a sensitive and specific assay for determination of glucocorticoid bioactivity. Wien Klin Wochenschr. 2011 Apr;123(7-8):222-9. doi: 10.1007/s00508-011-1562-y. PMID: 21465082.

Grespi F, Ottina E, Yannoutsos N, Geley S, Villunger A (2011). Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis. PLoS One. 2011 Mar 21;6(3):e18051. doi: 10.1371. PMID: 21445314.

Sánchez-Cabo F, Rainer J, Dopazo A, Trajanoski Z, Hackl H (2011). Insights into global mechanisms and disease by gene expression profiling. Methods Mol Biol. 2011;719:269-98. doi: 10.1007/978-1-61779-027-0_13. PMID: 21370089.

Kuster L, Grausenburger R, Fuka G, Kaindl U, Krapf G, Inthal A, Mann G, Kauer M, Rainer J, Kofler R, Hall A, Metzler M, Meyer LH, Meyer C, Harbott J, Marschalek R, Strehl S, Haas OA, Panzer-Grümayer R (2011). ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling. Blood. 2011 Mar 3;117(9):2658-67. doi: 10.1182/blood-2010-03-275347. PMID: 21224468.

Barisic M, Geley S (2011). Spindly switch controls anaphase: spindly and RZZ functions in chromosome attachment and mitotic checkpoint control. Cell Cycle. 2011 Feb 1;10(3):449-56. PMID: 21252629.

Prokudin I, Stasyk T, Rainer J, Bonn GK, Kofler R, Huber LA (2011). Comprehensive proteomic and transcriptomic characterization of hepatic expression signatures affected in p14 liver conditional knockout mice. Proteomics. 2011 Feb;11(3):469-80. doi: 10.1002/pmic.201000400. PMID: 21268275.

Eberhart K, Renner K: Dexamethasone-induced alterations in mitochondrial transport systems in childhood acute lymphoblastic leukemia. Biochim. Biophys. Acta Bioenergetics 2011 [Epub].

Kuster L, Panzer-Grumayer R: Genome wide copy number analysis reveals evolution of ETV6/RUNX1-positive relapses from an ancestral clone with frequent acquisition of deletions in genes implicated in glucocorticoid signaling. Blood 2011 [Epub].

2010

Aryee DNT, Niedan S, Kauer M, Schwentner R, Bennani-Baiti IM, Ban J, Muehlbacher K, Kreppel M, Walker RL, Meltzer P, Poremba C, Kofler R, Kovar H: Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing’s sarcoma cells in vitro. Cancer Res 2010, 70:4015-4023 PMID: 20442286.

Barisic M, Sohm B, Mikolcevic P, Wandke C, Rauch V, Ringer T, Hess M, Bonn G, Geley S: Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation. Mol. Biol. Cell 2010, 21:1968-1981 PMID: 20427577.

Carlet M, Janjetovic K, Rainer J, Schmidt S, Panzer-Grümayer R, Mann G, Prelog M, Meister B, Ploner C, Kofler R: Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells. BMC Cancer 2010, 10:638 PMID: 21092265.

Frenzel A, Labi V, Chmelewskij W, Ploner C, Geley S, Fiegl H, Tzankov A, Villunger A: Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Blood 2010, 115:995-1005 PMID: 19965635.

Grespi F, Soratroi C, Krumschnabel G, Sohm B, Ploner C, Geley S, Hengst L, Häcker G, Villunger A: BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis. Cell Death Differ 2010, 17:1672-1683 PMID: 20706276.

Mansha M, Carlet M, Ploner C, Gruber G, Wasim M, Wiegers GJ, Rainer J, Geley S, Kofler R: Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia. Leuk. Res 2010, 34:529-534 PMID: 19631983.

Wasim M, Carlet M, Mansha M, Greil R, Ploner C, Trockenbacher A, Rainer J, Kofler R: PLZF/ZBTB16, a glucocorticoid response gene in acute lymphoblastic leukemia, interferes with glucocorticoid-induced apoptosis. J. Steroid Biochem. Mol. Biol 2010, 120:218-227 PMID: 20435142.

2009

Eberhart K, Renner K, Ritter I, Kastenberger M, Singer K, Hellerbrand C, Kreutz M, Kofler R, Oefner PJ: Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis. Leukemia 2009, 23:2167-2170 PMID: 19657369.

Ecker K, Lorenz A, Wolf F, Ploner C, Böck G, Duncan T, Geley S, Helmberg A: A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein. J. Mol. Endocrinol 2009, 42:105-117 PMID: 19008334.

Gruber G, Carlet M, Türtscher E, Meister B, Irving JAE, Ploner C, Kofler R: Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of glucocorticoid-induced leukemia apoptosis. Leukemia 2009, 23:820-823 PMID: 19151768.

Haffner MC, Kronberger IE, Ross JS, Sheehan CE, Zitt M, Mühlmann G, Ofner D, Zelger B, Ensinger C, Yang XJ, Geley S, Margreiter R, Bander NH: Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers. Hum. Pathol 2009, 40:1754-1761 PMID: 19716160.

Kauer M, Ban J, Kofler R, Walker B, Davis S, Meltzer P, Kovar H: A molecular function map of Ewing’s sarcoma. PLoS ONE 2009, 4:e5415 PMID: 19404404.

Massoner P, Colleselli D, Matscheski A, Pircher H, Geley S, Jansen Dürr P, Klocker H: Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility. Endocr. Relat. Cancer 2009, 16:795-808 PMID: 19509068.

Obexer P, Hagenbuchner J, Rupp M, Salvador C, Holzner M, Deutsch M, Porto V, Kofler R, Unterkircher T, Ausserlechner MJ: p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2. J. Biol. Chem 2009, 284:30933-30940 PMID: 19737931.

Ploner A, Ploner C, Lukasser M, Niederegger H, Hüttenhofer A: Methodological obstacles in knocking down small noncoding RNAs. RNA 2009, 15:1797-1804 PMID: 19690100.

Ploner C, Rainer J, Lobenwein S, Geley S, Kofler R: Repression of the BH3-only molecule PMAIP1/Noxa impairs glucocorticoid sensitivity of acute lymphoblastic leukemia cells. Apoptosis 2009, 14:821-828 PMID: 19421859.

Rainer J, Ploner C, Jesacher S, Ploner A, Eduardoff M, Mansha M, Wasim M, Panzer-Grümayer R, Trajanoski Z, Niederegger H, Kofler R: Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia. Leukemia 2009, 23:746-752 PMID: 19148136.

Sigl R, Wandke C, Rauch V, Kirk J, Hunt T, Geley S: Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J. Cell. Sci 2009, 122:4208-4217 PMID: 19861496.

Subramanyam P, Obermair GJ, Baumgartner S, Gebhart M, Striessnig J, Kaufmann WA, Geley S, Flucher BE: Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells. Channels (Austin) 2009, 3:343-355 PMID: 19755859.

Weber A, Kirejczyk Z, Potthoff S, Ploner C, Häcker G: Endogenous Noxa Determines the Strong Proapoptotic Synergism of the BH3-Mimetic ABT-737 with Chemotherapeutic Agents in Human Melanoma Cells. Transl Oncol 2009, 2:73-83 PMID: 19412422.