2017

Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A. The PIDDosome activates p53 in response to supernumerary centrosomes.
Genes Dev.
2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116.   |  PMID: 28130345
 

Tuzlak S, Schenk RL, Vasanthakumar A, Preston SP, Haschka MD, Zotos D, Kallies A, Strasser A, Villunger A, Herold MJ. The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Cell Death Differ.
2017 Mar;24(3):523-533. doi: 10.1038/cdd.2016.155. Epub 2017 Jan 13.   |  PMID: 28085151
 

Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray DH, Tai L, Lew AM, Villunger A, Strasser A, Herold MJ. Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.
Cell Death Differ.
2017 Mar;24(3):534-545. doi: 10.1038/cdd.2016.156.  |   PMID: 28085150
 

Haschka MD, Villunger A. There is something about BOK we just don't get yet.
FEBS J.
2017 Mar;284(5):708-710. doi: 10.1111/febs.14031.  |  PMID: 28262002
 

Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, Kenner L, Villunger A, Sixt M, Kovarik P. The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.
J Clin Invest.
2017 May 15. pii: 80631. doi: 10.1172/JCI80631. [Epub ahead of print]   |   PMID: 28504646
 

Sochalska M, Schuler F, Weiss JG, Prchal-Murphy M, Sexl V, Villunger A. MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Oncogene.
2017 Apr;36(15):2066-2073. doi: 10.1038/onc.2016.362.  |  PMID: 27694901
 

Voráčová K, Hájek J, Mareš J, Urajová P, Kuzma M, Cheel J, Villunger A, Kapuscik A, Bally M, Novák P, Kabeláč M, Krumschnabel G, Lukeš M, Voloshko L, Kopecký J, Hrouzek P. The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells.
PLoS One.
2017 Mar 2;12(3):e0172850. doi: 10.1371   |   PMID: 28253280
 

2016

Tuzlak S, Schenk RL, Vasanthakumar A, Preston SP, Haschka MD, Zotos D, Kallies A, Strasser A, Villunger A, Herold MJ. The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Cell Death Differ.
2017 Jan 13. doi: 10.1038/cdd.2016.155. [Epub ahead of print]   |   PMID: 28085151
 

Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray DH, Tai L, Lew AM, Villunger A, Strasser A, Herold MJ. Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.
Cell Death Differ.
2017 Jan 13. doi: 10.1038/cdd.2016.156. [Epub ahead of print]   |   PMID:28085150
 

Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A. The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.
Cell Death Differ.
2016 Jan;23(1):41-51. doi: 10.1038/cdd.2015.61.   |   PMID: 26045049
 

Knackmuss U, Lindner SE, Aneichyk T, Kotkamp B, Knust Z, Villunger A, Herzog S. MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.
Cell Death Differ.
2016 Feb;23(2):242-52. doi: 10.1038/cdd.2015.87.   |   PMID: 26138442
 

Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A. Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Cell Death Differ.
2016 Apr;23(4):628-39. doi: 10.1038/cdd.2015.130.   |   PMID: 26450454
 

Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M. LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Cell Metab.
2016 Nov 8;24(5):657-671. doi: 10.1016/j.cmet.2016.08.011.   |   PMID: 27641098
 

Tuzlak S, Kaufmann T, Villunger A. Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis.
Genes Dev.
2016 Oct 1;30(19):2133-2151. Review.   |   PMID: 27798841
 

García Sáez AJ, Villunger A. MOMP in the absence of BH3-only proteins.
Genes Dev.
2016 Apr 15;30(8):878-80. doi: 10.1101/gad.281519.116.   |   PMID: 27083995
 

Sakamoto K, Wehde BL, Yoo KH, Kim T, Rajbhandari N, Shin HY, Triplett AA, Rädler PD, Schuler F, Villunger A, Kang K, Hennighausen L, Wagner KU. Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling. Mol
Cell Biol.
2016 May 16;36(11):1673-90. doi: 10.1128/MCB.00999-15.   |   PMID: 27044867
 

Podmirseg SR, Jäkel H, Ranches GD, Kullmann MK, Sohm B, Villunger A, Lindner H, Hengst L. Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion.
Oncogene.
2016 Sep 1;35(35):4580-90. doi:10.1038/onc.2015.524.   |   PMID: 26829051
 

Sochalska M, Schuler F, Weiss JG, Prchal-Murphy M, Sexl V, Villunger A. MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Oncogene.
2016 Oct 3. doi: 10.1038/onc.2016.362. [Epub ahead of print]   |   PMID: 27694901
 

Bauer E, Schlederer M, Scheicher R, Horvath J, Aigner P, Schiefer AI, Kain R, Regele H, Hoermann G, Steiner G, Kenner L, Sexl V, Villunger A, Moriggl R, Stoiber D. Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice.
Oncotarget.
2016 Mar 15;7(11):12191-205. doi: 10.18632/oncotarget.7687.   |   PMID: 26919255
 

Derudder E, Herzog S, Labi V, Yasuda T, Köchert K, Janz M, Villunger A, Schmidt-Supprian M, Rajewsky K. Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.
Proc Natl Acad Sci U S A.
2016 May 3;113(18):5065-70. doi: 10.1073/pnas.1604529113.   |   PMID: 27099294
 

Derudder E, Herzog S, Labi V, Yasuda T, Köchert K, Janz M, Villunger A, Schmidt-Supprian M, Rajewsky K. Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.
Proc Natl Acad Sci U S A.
2016 May 3;113(18):5065-70. doi: 10.1073/pnas.1604529113.   |   PMID: 27099294
 

García Sáez AJ, Villunger A. MOMP in the absence of BH3-only proteins.
Genes Dev.
2016 Apr 15;30(8):878-80. doi: 10.1101/gad.281519.116. Review.   |   PMID: 27083995
 

Sakamoto K, Wehde BL, Yoo KH, Kim T, Rajbhandari N, Shin HY, Triplett AA, Rädler PD, Schuler F, Villunger A, Kang K, Hennighausen L, Wagner KU. Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling. Mol
Cell Biol.
2016 May 16;36(11):1673-90. doi: 10.1128/MCB.00999-15. Print 2016 Jun 1.   |   PMID: 27044867
 

Bauer E, Schlederer M, Scheicher R, Horvath J, Aigner P, Schiefer AI, Kain R, Regele H, Hoermann G, Steiner G, Kenner L, Sexl V, Villunger A, Moriggl R, Stoiber D. Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice.
Oncotarget.
2016 Mar 15;7(11):12191-205. doi: 10.18632/oncotarget.7687.   |   PMID: 26919255
 

Podmirseg SR, Jäkel H, Ranches GD, Kullmann MK, Sohm B, Villunger A, Lindner H, Hengst L. Caspases uncouple p27Kip1 from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion.
Oncogene.
2016 Feb 1. doi: 10.1038/onc.2015.524.   |   PMID: 26829051
 

Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A. Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Cell Death Differ.
2016 Apr;23(4):628-39. doi: 10.1038/cdd.2015.130. Epub 2015 Oct 9.   |   PMID: 26450454
 

2015

Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A. Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Cell Death Differ.
2015 Oct 9. doi: 10.1038/cdd.2015.130.   |   PMID: 26450454
 

Fava LL, Rainer J, Haschka MD, Geley S, Villunger A. Beclin 1 is dispensable for chromosome congression and proper outer kinetochore assembly.
EMBO Rep.
2015 Oct;16(10):1233-6. doi: 10.15252/embr.201540731.   |  PMID: 26297610
 

Hermann-Kleiter N, Klepsch V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G. The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Cell Rep.
2015 Sep 29;12(12):2072-85. doi: 10.1016/j.celrep.2015.08.035.   |  PMID: 26387951
 

Woess C, Drach M, Villunger A, Tappert R, Stalder R, Pallua JD. Application of mid-infrared (MIR) microscopy imaging for discrimination between follicular hyperplasia and follicular lymphoma in transgenic mice.
Analyst.
2015 Sep 21;140(18):6363-72. doi: 10.1039/c5an01072a.   |  PMID: 26236782
 

Knackmuss U, Lindner SE, Aneichyk T, Kotkamp B, Knust Z, Villunger A, Herzog S. MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.
Cell Death Differ.
2015 Jul 3. doi: 10.1038/cdd.2015.87.   |  PMID: 26138442
 .

Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A. The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death.
Sci Rep.
2015 Jun 11;5:11268. doi: 10.1038/srep11268.   |  PMID: 26062895
 .

Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A. The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.
Cell Death Differ.
2015 Jun 5. doi: 10.1038/cdd.2015.61.   |  PMID: 26045049
 .

Amort M, Nachbauer B, Tuzlak S, Kieser A, Schepers A, Villunger A, Polacek N. Expression of the vault RNA protects cells from undergoing apoptosis.
Nat Commun.
2015 May 8;6:7030. doi: 10.1038/ncomms8030.   |  PMID: 25952297
 .

Haschka MD, Soratroi C, Kirschnek S, Häcker G, Hilbe R, Geley S, Villunger A, Fava LL. The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest.
Nat Commun.
2015 Apr 29;6:6891. doi: 10.1038/ncomms7891.   |  PMID: 25922916
 .

Peintner L, Dorstyn L, Kumar S, Aneichyk T, Villunger A, Manzl C. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
Cell Death Differ.
2015 Apr 10. doi: 10.1038/cdd.2015.31.   |  PMID: 25857265
 .

Woess C, Tuzlak S, Labi V, Drach M, Bertele D, Schneider P, Villunger A. Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice.
Cell Death Differ.
2015 Feb 20. doi: 10.1038/cdd.2015.8.   |  PMID: 25698446
 .

Piatti P, Lim CY, Nat R, Villunger A, Geley S, Shue YT, Soratroi C, Moser M, Lusser A. Embryonic stem cell differentiation requires full length Chd1.
Sci Rep.
2015 Jan 26;5:8007. doi: 10.1038/srep08007.   |  PMID: 25620209
 .

Ottina E, Sochalska M, Sgonc R, Villunger A. The BH3-only protein Bad is dispensable for TNF-mediated cell death.
Cell Death Dis.
2015 Jan 22;6:e1611. doi: 10.1038/cddis.2014.575.   |  PMID: 25611386
 

Sochalska M, Tuzlak S, Egle A, Villunger A. Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.
FEBS J
. 2015 Mar;282(5):834-49. doi: 10.1111/febs.13188. Epub 2015 Jan 23. Review.   |  PMID: 25559680
 .

Ottina E, Lyberg K, Sochalska M, Villunger A, Nilsson GP. Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.
J Immunol.
2015 Feb 1;194(3):1316-22. doi: 10.4049/jimmunol.1400637. Epub 2014 Dec 29.   |  PMID: 25548219
 .

Farrés J, Llacuna L, Martin-Caballero J, Martínez C, Lozano JJ, Ampurdanés C, López-Contreras AJ, Florensa L, Navarro J, Ottina E, Dantzer F, Schreiber V, Villunger A, Fernández-Capetillo O, Yélamos J. PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.
Cell Death Differ.
2015 Jul;22(7):1144-57. doi: 10.1038/cdd.2014.202. Epub 2014 Dec 12.   |  PMID: 25501596
 .

2014

Fava LL, Villunger A. Stop competing, start talking!
EMBO J.
2014 Sep 1;33(17):1849-51. doi: 10.15252/embj.201489466. Epub 2014 Jul 25. No abstract available.   |  PMID: 25063676
 

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H77, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
Cell Death Differ.
2014 Sep 19. Doi10.1038/cdd.2014.137   |  PMID:25236395
 .

Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H. BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.
EMBO J.
2014 Jul 23. pii: e201387244.   |  PMID:25056906
 

Labi V, Woess C, Tuzlak S, Erlacher M, Bouillet P, Strasser A, Tzankov A, Villunger A. Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.
Blood.
2014 Apr 24;123(17):2652-62.   |  PMID:24632712
 

Schweingruber N, Fischer HJ, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tuckermann JP, Flügel A, Lühder F, Reichardt HM. Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.
Acta Neuropathol.
2014 May;127(5):713-29.   |  PMID:24488308
 

Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W. Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1.
J Leukoc Biol.
2014 Jun;95(6):853-66 PMID:   |  PMID:24295829
 

2013

Baumgartner F, Woess C, Pedit V, Tzankov A, Labi V, Villunger A. Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Oncogene.
2013 Jan 31;32(5):621-30   |  PMID: 22430207
 

Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A. Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.
Cell Death Dis.
2013 Dec 5;4:e942   |  PMID: 24309929
 

Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W. Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1.
J Leukoc Biol.
2013 Dec 2   |  PMID: 24295829
 

Lindner SE, Wissler M, Gründer A, Aumann K, Ottina E, Peintner L, Brauns-Schubert P, Preiss F, Herzog S, Borner C, Charvet C, Villunger A, Pahl HL, Maurer U. Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.
Oncogene.
2013 Nov 11   |  PMID: 24213575
 

Fava LL, Haschka MD, Villunger A. Bim vanishes in the light of a mitotic Aurora.
Cell Death Differ.
2013 Dec;20(12):1597-8   |  PMID: 24212928
 

Wensveen FM, Geest CR, Libregts SF, Derks IA, Ekert PG, Labi V, Villunger A, Nolte MA, Eldering E. BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis.
Apoptosis
2013 Nov;18(11):1306-18   |  PMID: 23975731
 

Hannesdóttir L, Tymoszuk P, Parajuli N, Wasmer MH, Philipp S, Daschil N, Datta S, Koller JB, Tripp CH, Stoitzner P, Müller-Holzner E, Wiegers GJ, Sexl V, Villunger A, Doppler W. Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response. Eur
J Immunol.
2013 Oct;43(10):2718-29   |  PMID: 23843024
 

Ottina E, Pellegrini M, Villunger A. Guarding effector T-cell survival: all for one, Mcl-1 for all?
Cell Death Differ.
2013 Aug;20(8):969-71   |  PMID: 23832147
 

Egle A, Asslaber D, Villunger A, Pinon-Hofbauer J. Bid-ding for mercy: twisted killer in action.
Cell Death Differ.
2013 Jul;20(7):847-9   |  PMID: 23749178
 

Farrés J, Martín-Caballero J, Martínez C, Lozano JJ, Llacuna L, Ampurdanés C, Ruiz-Herguido C, Dantzer F, Schreiber V, Villunger A, Bigas A, Yélamos J. Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice.
Blood.
2013 Jul 4;122(1):44-54   |  PMID: 23678004
 

González-Gironès DM, Moncunill-Massaguer C, Iglesias-Serret D, Cosialls AM, Pérez-Perarnau A, Palmeri CM, Rubio-Patiño C, Villunger A, Pons G, Gil J. AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts.
Apoptosis
2013 Aug;18(8):1008-16   |  PMID: 23605481
 

Manzl C, Baumgartner F, Peintner L, Schuler F, Villunger A. Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines.
Methods.
2013 Jun 1;61(2):130-7   |  PMID: 23454286
 

Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A. Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage.
Cell Death Differ.
2013 Apr;20(4):546-57   |  PMID: 23238565
 

Labi V, Bertele D, Woess C, Tischner D, Bock FJ, Schwemmers S, Pahl HL, Geley S, Kunze M, Niemeyer CM, Villunger A, Erlacher M. Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf.
EMBO Mol Med.
2013 Jan;5(1):122-36   |  PMID: 23180554
 

2012

Baumgartner F, Woess C, Pedit V, Tzankov A, Labi V, Villunger A: Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Oncogene.
2012   |  PMID: 22430207
 .

Bock FJ, Peintner L, Tanzer M, Manzl C, Villunger A: P53-induced protein with a death domain (PIDD): master of puppets?
Oncogene.
2012   |  PMID: 22266869
 .

Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, Newbold A, Johnstone R, Villunger A: PIDDosome-independent tumor suppression by Caspase-2.
Cell Death and Differentiation
2012   |  PMID: 22595758
 .

Ottina E, Grespi F, Tischner D, Soratroi C, Geley S, Ploner A, Reichardt HM, Villunger A, Herold MJ: Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.
Blood
2012, 119:6032–6042   |  PMID: 22581448
 .

Ottina E, Tischner D, Herold MJ, Villunger A: A1/Bfl-1 in leukocyte development and cell death.
Exp. Cell Res.
2012, 318:1291–1303   |  PMID: 22342458
 .

Tischner D, Wiegers GJ, Fiegl H, Drach M, Villunger A: Mutual antagonism of TGF-beta and Interleukin-2 in cell survival and lineage commitment of induced regulatory T cells. Cell Death and Differentiation 2012   |  PMID: 22322859
 .

Tischner D, Gaggl I, Peschel I, Kaufmann M, Tuzlak S, Drach M, Thuille N, Villunger A, Jan Wiegers G: Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice.
J. Autoimmun.
2012, 38:59–69   |  PMID: 22257939
 .

2011

Baumgartner F, Villunger A: Apoptosis: a barrier against cancer no more?
Hepatology
2011, 54:1121–1124   |  PMID: 21898490
 

Villunger A, Labi V, Bouillet P, Adams J, Strasser A: Can the analysis of BH3-only protein knockout mice clarify the issue of “direct versus indirect” activation of Bax and Bak?
Cell Death Differ.
2011, 18:1545–1546   |  PMID: 21909118
 

2010

Frenzel A, Labi V, Chmelewskij W, Ploner C, Geley S, Fiegl H, Tzankov A, Villunger A: Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
Blood.
2010, 115:995-1005   |  PMID: 19965635
 

Hagenbuchner J, Ausserlechner MJ, Porto V, David R, Meister B, Bodner M, Villunger A, Geiger K, Obexer P: The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression.
J. Biol. Chem
2010, 285:6904-6912   |  PMID: 20051518
 

Karlberg M, Ekoff M, Labi V, Strasser A, Huang D, Nilsson G: Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis.
Cell Death Dis.
2010, 1:e43   |  PMID: 21364649
 

Krumschnabel G, Ebner HL, Hess MW, Villunger A: Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium.
Aquat. Toxicol
2010, 99:73-85   |  PMID: 20435356
 

Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, Egle A, Villunger A: Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation.
Genes Dev.
2010, 24:1602-1607   |  PMID: 20679395
 

Labi V, Villunger A: PUMA-mediated tumor suppression: A tale of two stories.
Cell Cycle
2010, 9:4269-4275   |  PMID: 20980816
 

Mansha M, Carlet M, Ploner C, Gruber G, Wasim M, Wiegers GJ, Rainer J, Geley S, Kofler R: Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia.
Leuk. Res
2010, 34:529-534   |  PMID: 19631983
 

Pafundo DE, Alvarez CL, Krumschnabel G, Schwarzbaum PJ: A volume regulatory response can be triggered by nucleosides in human erythrocytes, a perfect osmometer no longer.
J. Biol. Chem
2010, 285:6134-6144   |  PMID: 20040601
 

Parajuli N, Müller-Holzner E, Böck G, Werner ER, Villunger A, Doppler W: Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice.
Int. J. Cancer
2010, 126:896-908   |  PMID: 19653277
 

Podrabsky JE, Krumschnabel G: Cell death beyond worms, flies and humans: Unusual model systems for cell death research.
Apoptosis
2010, 15:243-248   |  PMID: 20140522
 

van Breukelen F, Krumschnabel G, Podrabsky JE: Vertebrate cell death in energy-limited conditions and how to avoid it: what we might learn from mammalian hibernators and other stress-tolerant vertebrates.
Apoptosis
2010, 15:386-399   |  PMID: 20127173
 .

Villunger A: Only the strong survive.
Immunity
2010, 32:729-731   |  PMID: 20620937
 

2009

Alvarez, PJ.,: Comparative analysis of P receptor-mediated induction of regulatory volume decrease in cells from teleosts and mammals.
Comparative Biochemistry and Physiology
2009:P. 29-29.

Erlacher, A.,: Displacement of wild type lymphopoiesis by bone marrow cells lacking the BH3-only proteins BIM or BMF but not puma.
Klinische Padiatrie
2009:P. 196-196.

Frenzel A, Grespi F, Chmelewskij W, Villunger A: Bcl2 family proteins in carcinogenesis and the treatment of cancer.
Apoptosis
2009, 14:584-596   |  PMID: 19156528
 

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL: Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.
Int. Immunol
2009, 21:715-725   |  PMID: 19454543
 

Krumschnabel G, Manzl C, Villunger A: Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase.
Oncogene.
2009, 28:3093-3096   |  PMID: 19581929
 

Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A: The enigma of caspase-2: the laymen’s view.
Cell Death Differ
2009, 16:195-207   |  PMID: 19023332
 

Krumschnabel G, Podrabsky JE: Fish as model systems for the study of vertebrate apoptosis.
Apoptosis
2009, 14:1-21   |  PMID: 19082731
 

Krumschnabel, HL.,: Metal-induced death in fish cells: Signalling pathways and mechanisms.
Comparative Biochemistry and Physiology
2009:P. 15-15.

Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J, Villunger A: Caspase-2 activation in the absence of PIDDosome formation. J.
Cell Biol.
2009, 185:291-303   |  PMID: 19364921
 

Nordigården A, Kraft M, Eliasson P, Labi V, Lam EW-F, Villunger A, Jönsson J-I: BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.
Blood.
2009, 113:2302-2311   |  PMID: 19064725
 

Shi M, Vivian CJ, Lee K-J, Ge C, Morotomi-Yano K, Manzl C, Bock F, Sato S, Tomomori-Sato C, Zhu R, Haug JS, Swanson SK, Washburn MP, Chen DJ, Chen BPC, Villunger A, Florens L, Du C: DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance.
Cell.
2009, 136:508-520   |  PMID: 19203584